British Air Force Typhoon FGR4s have operated alongside France's air force in a joint strike on an hidden munitions depot in Syrian territory operated by the IS group, according to the UK's MoD.
The site, identified by surveillance, was believed to be housing weapons and explosive materials, the statement said, and was located in hills just north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets employed laser-guided Paveway IV weapons to hit a several entry passages down to the site... early reports indicate the objective was successfully hit," officials stated.
There was no indication of any civilian casualties in the operation on Saturday evening and each participating jet returned to base without incident, the ministry further stated.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as the so-called Islamic State - enforced jihadist rule over parts of Iraq and Syria prior to its 2019 collapse.
"This operation underscores the UK's leading role, and determination to work closely with our partners, to eradicate any re-emergence of IS and their harmful and extremist ideologies in the region," the British Defence Secretary John Healey said.
British military aircraft have conducted surveillance missions over Syria to "deter any attempted comeback" of the group after its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I want to thank the personnel of our armed forces participating in this operation for their skill and their bravery," he added. "Including them were numerous British troops on duty over Christmas and New Year. This action, to take out terrorist threats who threaten our security, highlights how UK forces are prepared to act, continuously, keeping Britain secure domestically and powerful internationally."
Last December, the United States armed forces conducted what it described as a "large-scale strike" on Islamic State objectives in Syria, after an ambush resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The United Nations estimates IS still maintains an estimated 5,000 to 7,000 militants in both countries.
